温热伍用（60）￣Co照射对NSY42129人大肠癌细胞及其耐热细胞杀伤作用的研究

The Response of NSY42129 Human Colon Cancer Cells and itsThemnotolerant Cells to Single Hyperthermia and in Combination with 60Co Irradiation

应用不同剂量６０Ｃｏ（１５００ＣＧＹ，１００ＣＧＹ和５００ＣＧＹ）照射对ＮＳＹ４２１２９人大肠癌细胞及其耐热细胞的杀伤作用进行研究。结果表明：①１５００ＣＧＹ的６０Ｃｏ一次性照射即能杀伤ＮＳＹ４２１２９人大肠瘤细胞近５０％。②温热本身除能杀伤部分肿瘤细胞外，同６０Ｃｏ射线伍用还具有协同杀伤作用，其高、中、低不同剂量６０Ｃｏ对癌细胞的杀伤指数分别为６４．９％，５３．１％和５１．８％；而单纯照射组的仅为４６．１％、３９．２％和３７．６％，③耐热细胞对６０Ｃｏ照射不敏感，其高中低剂量６０Ｃｏ的细胞杀伤指数仅为２７．８％，２０．８％和１８．１％。

We used different dosages of 60Co irradiation(high dosage 1500 CGy,moderate dosage l,000 CGyand mild dosage 500 CGy to study its effects. The results were as follows(1)About half of the tumorcells were killedby usingl,500CGy once.(2) Hyperthermia alone could kill a part of tumor cells。it exerted a synergic function in killing tumor cells if combined with60Co irradiation The cell killingindex(CKI)was 64.9%,53.1%and 51.8%respectively。In comparison with single administration of60Co irradiation , the CKI was 46.1%,39.2%and 37.6%respectively。 (3) Thermotolerant cells were al- so in sensitive to60Co irradiation。The CKI was only 27.8%, 20.8%and 18.1%。