摘要
目的探讨心脏移植术后长期存活的患者冠状动脉病变的相关危险因素。方法回顾性分析32例心脏移植术后长期存活患者的临床资料,并对相关的临床因素进行评价,筛选出移植心冠状动脉病变的独立危险因素。结果高脂血症、热缺血时间、巨细胞病毒(CMV)抗体阳性、移植后时间及慢性排斥反应是移植心冠状动脉病变的危险因素,而年龄、高血压和糖尿病与移植心冠状动脉病变的相关性不明显;多元Losgitic回归分析,移植后时间和慢性排斥反应是移植心冠状动脉病变的独立危险因素(P<0.001,P=0.003)。结论心脏移植术后冠状动脉病变的实质是慢性排斥反应;与供心的热缺血时间、高脂血症及巨细胞病毒感染等相关。
Objective To evaluate the related risk factor of allograft coronary artery disease after heart transplantation.Methods Clinical data of 32 cases of coronary artery disease after heart transplantation were reviewed. Univariate analysis and multivariate Logistic regression analysis were made to evaluate the association of the clinical variables with CAV.Results Hypercholesteremia, survival, warm ischemia time, cytomegalovirus antibody positivity and the grade of chronic rejection were the related risk factors ( P < 0.05 ). Age, hypertention and diabetes were not the correlated risk factors ( P > 0.05 ). Multivariable predictors of CAV included survival ( P < 0.001 ) and the grade of chronic rejection ( P = 0.003 ).Conclusions Allograft coronary artery disease after heart transplantation is a kind of chronic rejection. It is correlated with the warm ischemia time, cholesterol, cytomegalovirus infection.
出处
《中华器官移植杂志》
CAS
CSCD
北大核心
2005年第6期342-343,共2页
Chinese Journal of Organ Transplantation
