注射HCG日血清雌二醇/孕酮比值与胚胎种植关系的临床研究

The Clinical Study of Relationship between Serum E_2/P Ratio on the Day of HCG Injection and Embryo Implantation

目的:探讨促排卵患者注射HCG日血清雌二醇/孕酮(E2/P)比值对内膜容受性的影响。方法:将132例体外受精助孕患者按促排卵周期注射HCG日血清E2/P比值分为6组,对其实验室结果及临床结局进行比较。结果:6组患者的平均年龄、受精率、卵裂率及移植胚胎数和评分均无差异,组1(E2/P<1)及组6(E2/P>5)的取卵数分别明显减少及增多,最终组1无一例妊娠,而组4(E2/P为3.01～4)获得了显著高于其他组的妊娠率和单胚种植率。结论:合适的E2/P比值可提高子宫内膜容受性,在促排卵周期监测二者水平对临床有重要指导意义。

Objective: To study the effect of serum E2/P ratio on the day of HCG injection in ovarian stimulation patients on embryo implantation.Met hods: 132 cases of IVF/ICSI were divided into six groups according t o serum E2/P ratio on H CG injection day, and compared their laboratory results and clinical outcomes. Results: There were no differences on average age, ferti lization rates, embryo cleavage rates, and quantity or quality of embryos transf erred in six groups. There was the least and the most oocyte in group 1 (E2/P <1) and group 6 (E2/P>5), respectively. No patient of group 1 got pregnancy finally, while those of group 4 (E2/P 3.01～4) got higher pregnancy rates and single embryo implantation ra tes than other five groups. Conclusions: The optimal E 2/P ratio on the day of HCG in jection can improve endometrial receptivity. So it's important to monitor it dur ing ovarian stimulation cycles.