人盲肠未分化腺癌细胞系（HCe－8693）的细胞遗传学研究

Cytogenetic Studies on a Human Cecum Adenocarcinoma Cell Line(ECe-8693)

对人盲肠未分化腺癌细胞系ＨＣｅ－８６９３）第２３代（早代）及１２５代（晚代）进行细胞遗传学研究，结果发现其染色体的数量分布比较集中，呈近二倍体核型，早代与晚代差别不大，染色体众数为４９。Ｇ显带核型分析结果表明，本细胞系比较接近于正常二倍体核型，异常染色体较少而有规律，易于进行核型分析。较明显的改变是第１号染色体短臂远端缺失及第１３号染色体三体性或部分三体性。

Human undifferentiated cecum adenocarcinoma cell line(Hce-8693) was established by Zhejiang Cancer Hospital in 1986. This paper reports the results of cytogenetic studies on the 23rd(early)and 125th(late) passages of this cell line. The numerical distribution range of chromosomes was rather narrow,showing a near diploid karyotype, and no significant difference was observed between early and late passages. The modal number of chromosomes was 49.G-banding karyotypic analysis revealed that the karyotype of this cell line was close to that of normal diploid cells,with few,easily identified abnormal chromosomes. The most significant changes were a distal deletion of the short arm of chromosome No.1 and a trisomy of chromosome No.13.The morphological characteristics and possible correlation with pathogenesis of colorectal cancer were briefly discussed.