丹参有效成份764－3对血小板聚集和花生四烯酸代谢产物的影响

The Effect of 764-3 on Platelet Aggregation and the Activity of Enzymes in Arachidonic Acid Metabolism

７６４－３是从中药丹参中提取的有效成份，对ＡＡ和ＡＤＰ诱导的家兔和人血小板聚集有明显抑制作用。在以ＡＡ为底物，猪肺微粒体供酶系统中，小剂量７６４－３（５－１００μｇ／ｍｌ）明显促进６－ｋｅｔｏ－ＰＧＦ１α的生成，剂量与效应相关。大剂量７６４－３（５００μｇ／ｍｌ）对ＴＸＢ２和６－ｋｅｔｏ－ＰＧＦ１α的生成都有抑制作用。结果提示：小剂量７６４－３可能有利于ＴＸＢ２和６－ｋｅｔｏ－ＰＧＦ１α平衡的调节。

is a purified compound extracted from Chinese herb Salvia miltiorrhizae.It was found to inhibite human and rabbit platelet aggregation induced by AA or ADP.Using AA as the substrate and pig lung microsome to provide enzymes,low doses of 764-3(5-100μg/ml)promoted the generation of 6-keto-PGF1α in a dose-dependant manner.At a dose of 500μg/ml,both TXB2 and 6-keto-PGF1α production were inhibited.The results suggest that low doses of 764-3 may be able to bring a balance between TXB2 and 6-keto-PGF1α.