摘要
764-3是从中药丹参中提取的有效成份,对AA和ADP诱导的家兔和人血小板聚集有明显抑制作用。在以AA为底物,猪肺微粒体供酶系统中,小剂量764-3(5-100μg/ml)明显促进6-keto-PGF1α的生成,剂量与效应相关。大剂量764-3(500μg/ml)对TXB2和6-keto-PGF1α的生成都有抑制作用。结果提示:小剂量764-3可能有利于TXB2和6-keto-PGF1α平衡的调节。
is a purified compound extracted from Chinese herb Salvia miltiorrhizae.It was found to inhibite human and rabbit platelet aggregation induced by AA or ADP.Using AA as the substrate and pig lung microsome to provide enzymes,low doses of 764-3(5-100μg/ml)promoted the generation of 6-keto-PGF1α in a dose-dependant manner.At a dose of 500μg/ml,both TXB2 and 6-keto-PGF1α production were inhibited.The results suggest that low doses of 764-3 may be able to bring a balance between TXB2 and 6-keto-PGF1α.
出处
《中国医学科学院学报》
CAS
CSCD
北大核心
1994年第2期140-143,共4页
Acta Academiae Medicinae Sinicae