可降解淀粉微球动脉栓塞机制的动态研究

Mechanism of arterial embolization with degradable starch microspheres: dynamic study with in vivo fluorescent microscopy

目的 动态研究可降解淀粉微球 (DSM )动脉栓塞的机制。方法 10只大鼠 ,经肠系膜上动脉注入DSM微粒后 ,应用荧光显微镜观察小肠黏膜终末小动脉内DSM微粒的动态变化及相应血流改变。结果 DSM可在动脉内形成大小不等的铸型 ,栓塞于不同大小的终末小动脉。DSM以碎片的形式降解。随着DSM的降解 ,终末小动脉内血流可完全恢复。结论 经动脉注入后 ,DSM降解主要表现为在涡流冲击下的物理裂解过程 .随着DSM及其裂解碎片进一步降解 。

Objective To observe the dynamic degradation process of degradable starch microspheres (DSM) in the terminal arterioles of small intestine and make the dynamic observation on the blood flow changes caused by DSM. Methods DSM was injected into the superior mesenteric artery (SMA) of ten rats from a branch of jejunal artery. Fluorescent microscopy was used to evaluate the dynamic changes of DSM and the blood flow in terminal arterioles of the small intestine. Results After intra-arterial injection, numerous DSM particles formed DSM casts with various size. Arterioles of small intestine were occluded by those casts. Debris of DSM discharged mainly from the proximal end of DSM casts. recanalization of the occluded arterioles could be recorded after DSM injection. Conclusion DSM can temporarily occlude terminal arterioles by casts formation. Degradation of DSM is directly demonstrated as a physical process. Recanalization of the occluded arterioles can be found with further degradation of DSM or its debris. Some debris might enter larger veins of the portal system through the terminal vein of the small intestine.