细胞外基质对离体大鼠睾丸支持细胞的影响

The Effects of Extracellular Matrix on Sertoli Cells of Rats in virtro

本实验利用组成细胞外基质的两种糖蛋白──纤维粘连蛋白和层粘连蛋白，以及来源于肝、肺组织的两种生物基质，在体外研究了细胞外基质对大鼠支持细胞的贴壁和铺展及形态的影响。结果证明两种糖蛋白均能促进支持细胞的贴壁和铺展。来源于肺组织的生物基质能在体外保留体内支持细胞的柱状细胞形态，而来自肝组织的生物基质则没有这种特性。

This study was performed to observe the effects of extracellular matrix(ECM)on Ser toli cells attachment,spreading and morphology in vitro.The ECM used were FN and LN and biomatrix isolated from the liver and lung.The results showed that FN and LN promot ed Sertoli cell attachment and spreading.The Sertoli cells grown on the biomatrix isolated from the lung assumed a columnar shape like that seen in vivo.The cells grown on biomatrix from the liver did not.