甲状旁腺移植供体组织的比较与选择

Human Parathyroid Allotransplantation:Comparison of Donor Grafts

从细胞分化程度、分泌功能和免疫原性３个方面对源于尸体（Ｃ－ＰＴＧ）、２０～２８周胎儿（Ｆ－ＰＴＧ）和甲状旁腺腺瘤（Ａ－ＰＴＧ）３种供体的甲状旁腺（ＰＴＧ）组织进行对比分析。结果表明：Ａ－ＰＴＧ组织中存在成簇或散在的分化幼稚细胞，具有癌变的可能性，不适宜临床移植。Ｃ－ＰＴＧ组织分泌功能好，Ｆ－ＰＴＧ组织免疫原性低，可作为移植供体。

The authors compared the degrees of cell maturity,antigenicity and secretory function of parathyroid (PTG)tissues from cadavers(C-PTG),20～28 wk fetus(F-PTG)and PTG adenoma(A-PTG).In A-PTG tissues, clustered or scattered immature cells were observed, but there were none in F-PTG and C-PTG. C-PTG and A-PTG tissues revealed better secretory function than F-PTG. No clear difference was found in HLA classⅠ(ABC)antigen quantity among the three donor PTG tissues, but the amount of HLA class Ⅱ(DR)antigen in A-PTG and F-PTG were significantly lower than that in C-PTG. The results demonstrate that C-PTG, with better function, and F-PTG, with lower antigenicity, can be used in clinical transplantation. A-PTG is not suitable for clinical transplantation due to their immaturity and possibility of carcinomatous change.