雷公藤氯内酯醇对大鼠异位心脏移植免疫抑制作用的实验研究

The Experimental Study of Immunosuppressive Effect of Tripcholorolide on the Cardiac Allograft Rats

本研究应用纯系大鼠（Ｌｏｕ→Ｆ３４４）心脏移植模型，比较分析了ＣｓＡ和不同剂量Ｔ４治疗组的移植心脏存活时间、病理损害计分以及移植受体大鼠脾单个核细胞ＩＬ－２生成活性和血清ｓＩＬ－２Ｒ水平，证实Ｔ４可明显延长移植心脏存活时间和减少移植排异反应程度。此研究结果表明Ｔ４具有较强的抗移植排异作用。

In order to confirm the anti-rejection effect of Tripcholorolide(T4),we compared the mean survival time of cardiac allograft,scores of pathological damage of the heart,the generation of IL-2 from splenocytes stimulated by ConA,and the serum level of slL-2R in the heart transplant model(Lou→F344)that received either cyclosporine or T4.The present study has shown that T4 could prolong the MST of cardiac allograft and significantly decrease the degrees of pathological damage of the transplant heart.The results indicated that T4 might be used as new anti-rejection drug in organ transplantation.