神经妥乐平治疗老年退变性颈椎病和腰椎管狭窄症的成本-效果分析

Cost-effectiveness Analysis of Three Pharmacotherapeutic Schemes for Senile Degenerative Cervical Spondylotic Myelopathy and Lumbar Spinal Stenosis

目的:探讨不同药物治疗方案治疗老年退变性颈椎病和腰椎管狭窄症的经济效果。方法:87例患者根据药物剂型、剂量和用药时间分为3组,A组为口服神经妥乐平片8U,2次/d,28d后停药;B组为口服神经妥乐平片8U,2次/d,14d后停药;C组为静脉滴注神经妥乐平注射液7.2U,1次/d,14d后停药。结果:A,B,C组治疗成本(C)分别为1876.00,938.00,1616.58元;总有效率(E%)分别为76.00%,66.67%,90.32%;单位效果所需成本(C/E)分别为24.68,14.07元,17.90元。在B组的基础上,A组和C组增加单位效果所需成本(△C/△E)分别为100.54,28.69元。结论:C组较B组的总有效率有较大提高,而且获得单位效果所需成本明显低于A组,故为较合理的用药方案。

Objective:To discuss the economic effects of different pharmacotherapeutic schemes for senile degenerative cervical spondylotic myelopathy and lumbar spinal stenosis.Methods:The clinical data of 87 cases of senile degenerative cervical spondylotic myelopathy and lumbar spinal stenosis in our department,are analyzed.According to the different kind and dose of drug and medication time,patients are divided into three groups,namely,group A——taking orally Neurotropin(8 U,twice a day) for 28 days,group B——taking orally Neurotropin(8u twice a day) for 14 d,and group C——transfusing via vein neurotropin(7.2 U once a day) for 14 d. The improvement of symptoms is observed.Data were evaluated using the pharmacoeconomic cost-effectiveness analysis.Results:The costs of three groups were 1 876.00,938.00 and 1 616.58 yuan respectively.The effective rates of three groups were 76.00%,66.67%and 90.32%respectively.Three schemes cost 24.68,14.07 and 17.90 yuan respectively for increasing 1%effective rate.On the basis of group B, group A and C cost 100.54 and 28.69 yuan respectively for increasing 1%effective rate.Conclusion:Among three schemes,the effective rate of group C was markedly higher than that group B.When increasing the same efficacy,group C cost lower expense than group A.So group C is a rational scheme.