摘要
含雌二醇的新颖膜控骨架型透皮给药系统（Ｅ２－ｍＴＤＤＳ），其人皮肤体外渗透动力学实验证明，雌二醇的透皮渗透呈零级动力学，且渗透速率与限速膜厚度的倒数呈良好线性关系（ｒ＝０．９９４）。因而该体系具有膜控型控释机理。
A new membrane-matrix controlled transdermal drug delivery system containing estradiol (E_2-mTDDS) has been developed recently.The results of permeation experiment of estradiol showed that the permeation of estradiol follows zero-order kinetics and the permeation rate is proportional to the reciprocal of the membrane thickness (r=0.994) So,this TDDS developed belongs to the membrane permeation-controlled mTDDS.
出处
《中国医药工业杂志》
CAS
CSCD
北大核心
1994年第1期8-10,共3页
Chinese Journal of Pharmaceuticals
关键词
雌二醇
渗透率
控释
机理
estradiol, permeation rate,controlled release,meedanism
