摘要
以雌二醇(E_2)阴道栓剂为阳性对照,雌三醇(E_3)阴道栓剂对去卵巢大鼠阴道粘膜作用的效价为4.58%;对去卵巢小鼠阴道粘膜作用的效价为20.27%;而对小鼠子宫增重作用的效价为3.4%,表明E_3栓剂阴道给药对小鼠阴道粘膜作用较强而对子宫增重作用较弱。
The effects of estriol pessary on the lower genital tract in rats and mice were observed. The results indicated that compared with estradiol the relative potencies of vaginal mucomembranous effect of estrfol pessary in ovariectomized rats and mice were 4.58% and 20.27%, respectively. while its relative potency of effect on uterine weight was 3.4%.The results showed that the effect of estriol pessacy on vaginal mucomembrane was stronger than that on the uterine weight.
出处
《中国医药工业杂志》
CAS
CSCD
北大核心
1994年第1期15-18,共4页
Chinese Journal of Pharmaceuticals