摘要
报道盐酸维拉帕米的重要中间体──Ｎ－甲基高藜芦胺的一种新的合成方法。系以愈创木酚为原料经甲基化、Ｆｒｉｅｄｅｌ－Ｃｒａｆｔｓ酰化反应、改良的Ｗｉｌｌｇｅｒｏｄｔ－Ｋｉｎｄｌｅｒ反应和还原脱硫反应制得。
N-Methyl-2-(3,4-dimethoxyphenyl) ethyl amine, a key intermediate for manufacturing verapamil hydrochloride, was prepared from guaiacol by four steps, i.e,o-methylation, Freidel-Crafts acylation, modified Willgerodt-Kindler reaction and reductive desulfurization.
出处
《中国医药工业杂志》
CAS
CSCD
北大核心
1994年第2期54-57,共4页
Chinese Journal of Pharmaceuticals
关键词
N-甲基高藜芦胺
盐酸维拉帕米
合成
N-methyl-2-(3,4-dimethoxyphenyl) ethylamine, verapamil hydrochloride, synthesis
