2－甲基－3（2H）－异噻唑酮和5－氯衍生物的合成

SYNTHESIS OF 2-METHYL-3(2H)-ISOTHIAZO-LONE AND ITS 5-CHLORO DERIVATIVE

以丙烯酸甲酯为原料，经酰胺化反应、Ｍｉｃｈａｅｌ加成反应、氯化环合反应合成２－甲基－３（２Ｈ）－异噻唑酮及其５－氯衍生物。初步探讨了反应物配比，反应温度及时间等因素对产物收率的影响。

Methyl-3(2H )-isothiazolone and its 5-chloro derivative were synthesized from methyl acrylate by amidation, Michael addition and chlorinationcyclization.The optimum reaction conditions were disscused.