雷公藤单体T_4及人工麝香对实验变态反应性神经炎的治疗作用

Effects of T_4 Monomer of Tripterygium Wilfordii and Artificial Musk on Experimental Allergic Neuritis

雷公藤单体Ｔ４及人工麝香具有调节免疫机制及抗炎作用，人工麝香越早应用其抗炎作用越强，根据此两种药的药理特性及实验变态反应性神经炎（ＥＡＮ）的发病机制，本实验设立了５组进行比较：即发病假治组、人工麝香预防及治疗组、地塞米松及雷公藤单体Ｔ４治疗组。结果：Ｔ４单体可使ＥＡＮ动物模型发病兔临床评分减低，对炎细胞渗出及脱髓鞘均有明显改善，与地塞米松相似，尽管人工麝香对ＥＡＮ的临床和病理变化有轻微的预防及治疗作用，但与假治组无统计学差别。提示地塞米松及Ｔ４单体有肯定的治疗价值，而人工麝香的预防及治疗价值不肯定。

Both T4 monomer of Tripterygium wilfordii and artificial musk had effects in regulating immune system and anti-inflammation.The effect of using artificial musk was the earlier the stronger.According to pharmacological features of the two drugs and pathogenesis of experimental allergic neuritis(EAN),5 experimental groups were established,i.e.,artificial musk prevented and treated groups,dexamethasone and T4 monomer treated groups,and control group.Results:T4 monomer could reduce the clinical score of model rabbits of EAN and significantly ameliorated inflammatory cell infiltration and demyelination.It was similar to dexamethasone.Although artificial musk had mild preventing and treating effects on the clinical and pathological changes of EAN, but was not statistically significant in comparing with control group.Our clinical or pathological data suggested that T4 monomer and dexamethasone were effective in the treatment of EAN,and that of artificial musk in preventing and treating EAN as indefinite.