101－B毛发再生精的皮肤毛发药理作用研究

Studies on Pharmacological Action of 101-B Hair Regeneration Extract on Skin and Hair in Experimental Animals

本实验研究了１０１－Ｂ毛发再生精的皮肤毛发药理作用。结果表明，１０１－Ｂ毛发再生精连续用药１０～１８天对正常大鼠、豚鼠和家兔有促进体毛生长作用，并能预防灌服碳酸铊所致大鼠体毛脱落。对组织胺和木瓜酶诱发豚鼠痒反应有止痒作用。对正常及内毒素所致微循环障碍小鼠的耳廓微循环有改善作用。对阿霉素引起的大鼠皮肤溃疡有保护作用。这些作用机理的阐明为其临床应用提供了依据。

Pharmacological action of 101-B hair regeneration extract(101-B) on skin and hair was studied in experimental animals.The results were as follows.(1) In normal rats,guinea pigs and rabbits the weight of regrown hairs in shaved area in 101-B group was significantly heavier than that in alcohol group.(2) Hair loss induced by oral administration of thallium carbonate 2 mg/kg every other day for 10 times was obviously prevented by topical treatment of 101-B.(3) Itching threshold to histamine or papain in guinea pig was elevated after using of 101-B topically.(4) The diameter of skin ulcer caused by intradermal injection of adriamycin in rats was diminished in 101-B group.(5) Observation in skin microcirculation in mice indicated that both normal skin microcirculation and disturbed microcirculation induced by endotoxin were improved with administration of 101-B.Above experimental results provided preliminary evidence for clinical use of 101-B.