慢性肾功能衰竭和血液透析患者脑干听觉诱发电位及“肾”与耳关系探讨

Significance of Brainstem Auditory Evoked Potential Determination in Chronic Renal Failure and Maintenance Hemodialysis Patients

根据中医学“肾开窍于耳”的理论，我们分别测定了慢性肾功能衰竭（肾衰）和维持血液透析患者的脑干听觉诱发电位（ＢＡＥＰ）。２０例慢性肾衰患者ＢＡＥＰ明显异常者１３例，异常４例，主要表现为Ⅰ、Ⅲ、Ⅴ主波潜伏期（ＰＬｓ）延长及Ⅰ－Ⅲ、Ⅰ－Ⅴ峰间潜伏期（ＩＰＬｓ）延长；８例平均血液透析４．２月者透析前后同体比较，透析后Ⅲ、ⅤＰＬｓ和Ⅰ－Ⅲ、Ⅰ－ⅤＩＰＬｓ缩短有显著性意义。各ＰＬｓ及ＩＰＬｓ与生化指标无显著相关性。ＢＡＥＰ测定及其动态观察为判断肾衰时内耳和听觉神经系统损害提供了客观指标，亦为中医“肾”与耳关系学说提供了电生理研究的佐证。

Brainstem auditory evoked potentials (BAEP) were measured in 20 chronic renal failure patients and 8 maintenance hemodialysis patients.The BAEP in chronic renal failure patients was showed that wave Ⅰ,Ⅲ,Ⅴ peak latencies(PL) and Ⅰ-Ⅲ,Ⅰ-Ⅴ interpeak latencies(IPL) were markedly increased..The significant reductions,although not to normal,of wave Ⅲ,Ⅴ PL and Ⅰ-Ⅲ,Ⅰ-Ⅴ IPLwere recorded in postdialysis(average 4.2 months) compared with that in predialysis.A correlation analysis revealed no consistent relationships between plasma proteins,hemoglobin,urea,creatinine serum electrolytes and BAEP PL or IPL.The authors realize that BAEP could be used as a subjective index in deciding the inner ear and nervous system damage in chronic renal failure,and it also provided an electrophysiologic evidence for the relationship of Kidney and ear in traditionalChinese medicine.