托吡酯药物定量脑电图研究的非线性分析

Quantitative electroencephalography effects of topiramate: a nonlinear analysis

目的探讨托吡酯对人类脑电图复杂性的影响。方法应用药物定量脑电图的方法,用非线性分析方法对12例癫患者和16名健康人单次口服托吡酯前后脑电图的复杂度,近似熵,李氏指数,分形维数变化进行动态观察和研究。结果托吡酯对脑电图复杂性的影响表现为李氏指数先升高,再降低,再升高,升高有统计学意义(健康人双中央最大值0.44,P<0.01);分形维数和近似熵有下降趋势;复杂度健康人降低(右顶最小值0.34),患者升高(右后颞最大值0.34)。结论托吡酯对人类的脑电复杂性有影响。

ObjectiveTo investigate the effects of topiramate (TPM) on complexity of electroencephalography (EEG) by means of quantitative pharmacoelectroencephalography (QPEEG) and nonlinear analysis methods.MethodsOne dose of TPM was administrated to epileptics and healthy adults. The EEG samples were obtained prior to and at regular intervals (at 0.5, 1, 2, 4, 6, 8, 12, 24 hours after the administration) within 24 hours following the administration of TPM. The EEG activity was processed with the nonlinear analysis methods. The complexity measure, approximate entropy, Lyapunov exponent and fractional dimension of the whole scalp areas were calculated through 60 seconds epochs without artifacts after each recording. The statistical difference between baseline predrug assessment and each postdrug control was described by analysis of variance.ResultsThe Lyapunov exponent was increased first, then decreased, and then increased finally (the maximum value was 0.44 in both centrals in the healthy people). The approximate entropy and fractional dimension showed the tendency of descent, the complexity measure decreased in healthy adults (the least value was 0.34 on right parietal), but increased in patients (the maximum value was 0.34 in right posterior temporal).ConclusionTPM might change the complexity of EEG.