呼吸系疾病患者血清神经节苷脂与癌胚抗原

Quantities of serum gangliosides and carcino-embryonic antigen in patients withrespiratory diseases

目的:研究呼吸系疾病患者血清神经节苷脂(gangliosides,GLS)与癌胚抗原(car-cinoembryonicantigen,CEA)含量及意义。方法:测定患者血清GLS、CEA,分组统计分析。结果:恶性肿瘤、结核、肺炎、慢性支气管炎组血清GLS含量分别为(908±300)、(755±316)、(820±294)、(570±147)mg/L;阳性率分别为87·8%、42·8%、61·1%和23·4%。四组血清CEA含量分别为(19·3±20·1)、(10·7±5·6)、(11·7±8·4)和(10·9±9·9)μg/L;阳性率分别为39·1%、20·0%、13·9%和18·8%。恶性肿瘤组中肺癌患者GLS含量及阳性率呈现未分化癌>鳞癌>腺癌,CEA正相反。GLS和(或)CEA阳性在恶性肿瘤组占92·2%,可作肺癌初筛指标;GLS和CEA阳性在恶性肿瘤组占34·8%,在非癌各组总计占5·8%,可作肺癌诊断指标。结论:肺癌患者血清GLS显著增加,对肺癌诊断有一定意义;GLS与CEA联合检测对肺癌诊断可能更有价值。

OBJECTIVE:To study the quantities and clinical values of serum gangliosides (GLS) and carcino-embryonic antigen (CEA) in patients with respiratory diseases.METHODS: The serum GLS and CEA were determined and statistically analyzed on groups of the patients.RESULTS: Serum GLS in cancers, tuberculosis, pneumonia and chronic bronchitis groups were (908±300), (755±316), (820±294) and (570±147) mg/L; the positives were 87.8%, 42.8%, 61.1% and 23.4%, respectively. Serum CEA in these groups were (19.3±20.1), (10.7±5.6), (11.7±8.4) and (10.9±9.9) μg/L; the positive rates were 39.1%, 20.0%, 13.9% and 18.8%. The quantitive rates and positives of GLS in lung cancer group showed: low-differentiated cancer>scaled cell cancer>adenoid cancer; and it was just opposite for CEA. The GLS and/or CEA positive rates in lung cancer group was 92.2%, and the GLS and CEA positive rates were 34.8% in cancer group and only 5.8% in all other groups.CONCLUSIONS: The quantities of serum GLS increased evidently in lung cancers patients are valuable for diagnosis. It may be of more significance for the diagnosis of lung cancer to assay GLS together with CEA.