草酸铂联合氟尿嘧啶和醛氢叶酸双周疗法治疗晚期大肠癌46例临床观察

Semimonthly eloxatin combined with 5-fluorouracil/leucovorin in treatment of advancedcolorectal cancer: a report of 46 cases

目的:评价草酸铂(L-OHP)联合5-氟尿嘧啶(5-FU)/醛氢叶酸(LV)双周疗法治疗晚期大肠癌的疗效。方法:采用L-OHP联合5-FU/LV双周疗法治疗经病理检查确诊的晚期大肠癌46例,所有患者均有可评价病灶。治疗方案为L-OHP85mg/m2,静脉滴入2h;LV200mg/m2,静脉滴入2h;5-FU500mg,静脉推注10min;5-FU3·0g/m2,静脉持续灌注46h。以上方案每2周重复1次,每2次为1个疗程,所有患者至少接受2个疗程的治疗。结果:46例可评价疗效:CR6例,PR16例,NC18例,PD6例,CR+PR为47·8%(22/46)。不良反应主要为周围神经毒性、恶心和呕吐、骨髓抑制和腹泻。结论:L-OHP联合5-FU/LV双周疗法治疗晚期大肠癌患者,疗效好,不良反应轻。

OBJECTIVE:To evalute the efficacy and the toxicity of eloxatin (L-OHP) combined with semimonthly 5-fluorouracil/leucovorin (5-FU/LV) in the treatment of patients with advanced colorectal cancer (ACRC). METHODS: Forty-six patients with ACRC proved pathologically were enrolled into this study. The chemotherapy regimen was comprised of L-OHP 85 mg/m^2 iv. in a 2-hour infusion followed by 2-hour infusion of LV 200 mg/m^2 then 10-minute intravenous bolus of 5-FU 500 mg, then 46-hour infusion of 5-FU 3.0 g/m^2 using an ambulatory pump. The regimen was given per 14 days. One cycle consisted of twice chemotherapy regimens. All enrolled patients received at least two cycles of the treatment. RESULTS: Forty-six cases were evaluable for efficacy: CR 6 cases, PR 16 cases, NC 18 cases, PD 6 cases. The overall response rate (CR+PR) was 47.8%. The main side effects were neurosensory toxicity, mucositis, nausea and vomiting, bone marrow suppression and diarrbea. CONCLUSIONS: Semimonthly L-OHP combined with 5-FU/LV is a safe and effective therepy for patients with ACRC.