BPH组织无症状性炎症的模式及临床意义

Asymptomatic inflammation in benign prostatic hyperplasia

目的:揭示BPH患者前列腺组织无症状性炎症的模式及临床意义。方法:对40例BPH患者经TURP或开放手术获取的前列腺标本行白细胞共同抗原(LCA)免疫组织化学染色,并对前列腺组织内的炎细胞应用图像分析系统进行扫描,计算炎细胞面积占整个切片面积的百分比。结果:40例患者前列腺组织均有明显的炎细胞浸润,炎症模式分为腺周围型(34/40)、腺型(26/40)和基质型(23/40),约近一半的患者(18/40)在同一张切片上可以同时见到明显的二种甚至三种炎症类型改变。炎细胞面积在前列腺细菌培养阳性者和阴性者之间、术前留置导尿管者和未留置导尿管者之间的差异均无统计学意义(均P>0.05)。结论:BPH患者前列腺组织的炎细胞浸润是非常常见的组织学改变,这种无症状性前列腺炎与BPH关系密切,其临床意义有待进一步确定。

Objective:To determine the pattern and clinical significance of asymptomatic inflammation in benign prostatic hyperplasia (BPH).Methods:Histological sections were obtained from 40 cases of BPH specimens collected prospectively at transurethral resection of the prostate(TURP) or suprapubic prostatectomy. Leukocyte common antigen(LCA) was demonstrated by immunostaining and the percentage of inflammation tissue area in the total specimen were measured with a computerized image-analysis system.Results:Inflammation was identified in all patients. Foci of inflammation were categorized as periglandular(34/40), glandular(26/40)and stromal (23/40). There was no significant difference between any combination of inflammation pattern and extent in those culture-positive and culture-negative cases (P>(0.05)) or catheterized or not (P>(0.05)).Conclusions:Prostatic inflammation is an extremely common histological finding in patents with symptoms of BPH. The clinical significance of asymptomatic chronic prostatitis associated with BPH awaits further determination.