胰必清颗粒对实验动物胃肠运动的影响

Effects of Yibiqing Grain on the Motion of Gastro|intestines in Experimental Animals

目的:研究胰必清颗粒对实验动物胃排空、小肠推进功能、湿粪计数、离体小肠平滑肌活动的影响。方法:灌胃给药后,测定小鼠胃内容物的残留率、小肠中阿拉伯胶活性炭粉混合物的推进距离及湿粪计数的变化情况;制作豚鼠回肠离体肠段标本,测定给药前后肠段平滑肌收缩强度和频率的变化情况。结果:胰必清颗粒可使小鼠胃残留率明显减少,小肠推进百分比和湿粪计数颗粒明显增加(P<0.05或P<0.01),同时能增强豚鼠离体小肠平滑肌收缩强度(P<0.05)。结论:胰必清颗粒具有明显的促进动物胃肠运动作用。

Objective: To investigate the effects of the Yibiqing grain, a combined traditional Chinese medicine, on gastric emptying, intestinal propulsion, counts of damp excrement and movement of isolated small intestine smooth muscle in experimental animals. Methods: After the Yibiqing grain were administrated orally, the remaining rate of substance in stomach, the distance that the mixture of Arabian gel and active charcoal powder in intestines was carried forward and the counts of damp excrement were measured. The samples of isolated ileum segment from guinea pigs were prepared, then the contraction intensity and frequency of gut smooth muscle were measured pre- and post-treatment of the Yibiqing grain. Results: The Yibiqing grain could significantly improve gastric emptying, accelerate the intestinal propulsion and increase counts of damp excrement in mice (P<0.05, P<0.01). Furthermore, it could significantly reinforce the contraction intensity of isolated small intestine smooth muscle in guinea pigs (P<0.05). Conclusion: The Yibiqing grain has the function of promoting the motion of gastro-intestines in the experimental animals.