摘要
以2-氨基-5-硝基二苯酮为原料,经卤乙酰化、环合和成盐精制得硝基安定。比较了氯乙酰氯和溴乙酰溴对中间体及硝基安定收率的影响。
Nitrazepam was synthesized from 2-amino-5-nitrobenzophenone by haloacetylation, cyclization, and purification via salt formation.The effect of chloroacetyl chloride and bromoacetyl bromide on yields of intermediates and nitrazepam was compared.
出处
《中国医药工业杂志》
CAS
CSCD
北大核心
1994年第12期531-533,共3页
Chinese Journal of Pharmaceuticals
关键词
硝基安定
合成
二苯酮
氯乙酰氯
溴乙酰溴
nitrazepam, synthesis, 2-amino-5-nitrobenzophenone, chloroacetyl chloride, bromoacetyl bromide