Beta-Cetnin和APC蛋白在卵巢上皮肿瘤中的表达及意义

Expression of beta-catenin protein APC in ovarian epithelial tumor and its implication

目的:探讨卵巢良性上皮肿瘤,卵巢交界性上皮肿瘤及卵巢恶性上皮肿瘤中beta-Catenin和APC蛋白的表达及意义。方法:采用ABC免疫组织化学染色方法检测18例卵巢良性上皮肿瘤,13例卵巢交界性上皮肿瘤及17例卵巢恶性上皮肿瘤中beta-Catenin和肿瘤APC蛋白的表达。结果:卵巢恶性上皮肿瘤beta-Catenin异常表达率明显高于卵巢良性上皮肿瘤(P<0.001),卵巢交界性上皮肿瘤beta-Catenin异常表达率亦明显高于卵巢良性上皮肿瘤(P<0.01);APC蛋白在卵巢良性上皮肿瘤的表达明显强于卵巢恶性上皮肿瘤,两者具有显著性差异(P<0.05);卵巢上皮肿瘤中beta-Catenin和APC蛋白之间存在负相关,且具有统计学意义(r=-0.352,P<0.05)。结论:beta-Catenin,APC蛋白在卵巢上皮肿瘤的发生,发展过程中起重要作用。

Objective:To investigate the expression of beta-catenin,protein APC and its implication in ovarian epithelial tumor.Methods:Immunohistochemical staining with ABC method was conducted to determine the expression of beta-catenin and protein APC in 48 cases of ovarian epithelial tumors.Results:The rate of beta-catenin in ovarian malignant epithelial tumor was higher than that in benign epithelial tumor,and the rate in borderline epithelial tumor was higher than that in benign epithelial tumor too.There was significant difference between them.The prevalence of protein APC positive in ovarian benign epithelial tumor was significantly greater than that in ovarian malignant epithelial tumor.A significant negative correlation was found between beta-catenin and protein APC in ovarian epithelial tumor.Conclusion:The results suggest that beta-catenin and APC protein have important effects on pathogenesis and development of ovarian epithelial tumors.