创伤性兔股动脉瘤、动静脉瘘模型的建立及相关研究

Establishment of experimental femoral pseudoaneurysm and arteriovenous fistula model in rabbit and its related study

目的:探讨建立实验性兔股动脉瘤、动静脉瘘模型的可行性,并进行相关研究。方法:用显微外科技术在40只新西兰白兔股部建立股动脉瘤、股动静脉瘘模型,行模型的血流探测,血气分析,彩色多谱勒血流成像(CDFI),CTA,MRA,DSA检测,并行组织学观察。结果:20只新西兰白兔中成功制作动脉瘤16个,成功率80%,20只新西兰白兔中全部成功制作股动静脉瘘,并经相关检测手段证实。结论:显微外科技术建立兔股动脉瘤,动静脉瘘模型切实可行,检测方法上表现各具特点。

Objective:To explore the possibility of establishment of experimental femoral pseudoaneurysm (PA)and arteriovenous fistula (AVF) models in rabbits and to make the related study.Methods:Experimental PA and AVF models were established in rabbits with microsurgical technique.Models were analyzed by blood gas analysis,checked by color Doppler flow imaging(CDFI),examined by computed tomography angiography(CTA),magnetic resonance angiography (MRA),digital subtraction angiography(DSA) and histological observation.Results:16 of 20 femoral pseudoaneurysms and 20 arteriovenous fistulae were successfully anastomosed and were confirmed by related examination methods.Conclusion:It is possible to establish experimental model in rabbit with microsurgery technique and each of examination methods has its own characteristics.