非小细胞肺癌中p53、bcl-2的表达

Expressions of p53 and bcl-2 in non-small-cell lung cancer

目的:研究p53、bcl-2在非小细胞肺癌(NSCLC)中的表达及其相关性,以探讨其在肺癌的发生、发展中所起的作用及其与凋亡的关系。方法:选取手术切除术后联合放疗±化疗的NSCLC病例共56例,运用免疫组织化学方法(SP法)检测术后病理标本中p53、bcl-2的表达,分析二者在NSCLC中表达的相关性及其与凋亡的关系。结果:p53阳性表达率55.36%(31/56),bcl-2阳性表达率53.57%(30/56)。p53,bcl-2的表达无相关性(P>0.05),二者与患者的临床病理特征无相关性(P>0.05)。结论:p53、bcl-2与NSCLC的发生、发展有关。p53、bcl-2的表达无相关性,可能提示bcl-2对细胞凋亡的调控作用可能与p53有不同的作用机制。

Objective:To study expressions and correlations of p53 and bcl-2 in NSCLC and to discuss their significance in oncogenesis and progression of lung cancer and apoptosis.Methods:56 surgically resected NSCLC patients treated with radiotherapy ± chemotherapy were enrolled in the study group.The expressions of p53 and bcl-2 were tested by immunohistochemical SP method.The correlation of expressions and their relationship with apoptosis in NSCLC were analyzed.Results:Positive expressions of p53 and bcl-2 were 55.36%(31/56) and 53.57%(30/56) respectively.There was no significant difference between p53 and bcl-2(P>0.05).Significant correlations were not found between their expressions and clinical pathological characteristics(P>0.05).Conclusion:p53 and bcl-2 have relationship with oncogenesis and progression of NSCLC.p53 and bcl-2 have no significant correlation,which suggests that bcl-2 has control mechanism for apoptosis different from p53.