摘要
目的:优选睾酮霜的基质配方及生产工艺条件。方法:以乳膏剂的稳定性及外观性状为考察指标,采用正交设计法进行实验。以油相配比、乳膏剂用量、主药的加入方式为可变因素。结果:最优的基质配方及工艺为A1B2C2或A1B3C3。结论:制备的睾酮霜符合中国药典2000版有关软膏剂的规定[1]。
Objective:To choose the prescription of the optimum testosterone propionate frost and the production craft conditions.Methods:Take the stability and the external appearance forms of the creams as the index sign to be checked,and carry out the experiment with orthogonal test.With the oil matches each other the ratio,the creams dosage,the way to add the main medicine a variable factor.Results:The superior formulation and craft are A 1B 2C 2 or A 1B 3C 3.Conclusion:The ready frost of testosterone propionate meets the provision of the Chinese Medical Dictionary 2000 on relevant ointments.
出处
《重庆医科大学学报》
CAS
CSCD
2005年第3期463-464,共2页
Journal of Chongqing Medical University
关键词
正交实验
睾酮霜
基质配方
工艺条件
Orthogonal test
Frost of testosterone propionate
Bases prescription
Craft condition