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不同时期神经视网膜免疫抗原分子表达特性 被引量：2

Expression characteristic of antigen molecules of neural retina in different developing stage
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摘要 目的探讨MHC-Ⅰ、MHC-Ⅱ及CD45分子免疫相关抗原在新生1d及10周龄C57BL/6小鼠神经视网膜表达的变化。方法新生1d及10周龄C57BL/6小鼠神经视网膜悬液细胞培养48h后行流式细胞仪检测3种免疫相关抗原的表达。结果新生1d神经视网膜可少量表达MHG-Ⅰ、MHC-Ⅱ及CD45。10周龄神经视网膜可表达MHC-Ⅰ、MHC-Ⅱ及CD45,其表达量均明显高于新生1d组。结论新生期神经视网膜中,相关抗原表达量明显低于成年小鼠组,免疫原性较低,适宜做视网膜移植的供体材料。 Objective To study the difference of MHC-I, MHC-Ⅱ and CD45 expression on the neural retina between newborn and post-natal 10 weeks C57BL/6 mouse. Methods Three kinds of antigens of neural retina were examined by flowcytometry after retinal neural cells were cultured for 48 hours. Results Neonatal mouse retina had a low expression of MHC-Ⅰ, MHC-Ⅱ and CD45.MHC-Ⅰ, MHC-Ⅱ and CD45 expression could be found on the 10 weeks mouse retina. Compared with newnatal retina, the three antigens expression on adult retina were much more. Conclusion The newnatal retina has more lower antigens expression about immune than adult one. So it is less immunogenic than adult one. The newnatal retina is appropriate donor material for retina transplantation.
作者 白大勇 李根林 刘月月
机构地区 首都医科大学附属北京同仁眼科中心
出处 《眼科新进展》 CAS 2005年第3期216-218,共3页 Recent Advances in Ophthalmology
基金 国家自然科学基金资助(编号:30371510)北京市自然科学基金(编号:7042020)国家"十.五"攻关专题计划(编号:2001BA705810)~~
关键词 免疫赦免 小鼠 抗原 神经视网膜 immune privilege mouse antigen neural retina
分类号 R774 [医药卫生—眼科]
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参考文献8

  • 1Kwan AS,Wang S,Lund RD.Photoreceptor layer reconstruction in a rodent model of retinal degeneration[J].Exp Neurol 1999;159(1):21-33.
  • 2白大勇,李根林.视网膜下腔免疫赦免机制的研究进展[J].国外医学（眼科学分册）,2004,28(4):272-275. 被引量：1
  • 3陈慰峰.医学免疫学[M].人民卫生出版社,2001,2第三版.29-34.
  • 4安云庆.免疫学基础[M].北京:北京科学技术出版社,2000.141.
  • 5Illigens BM,Ymada A,Biosgeraut F,Fedoseyeva EV,Anosova N,Valujskikh A.The relative contribution of direct and indirect antigen recognition pathways to the alloresponse and graft rejection depends upon the nature of the transplant[J].Hum Immunol 2002;63:912-915.
  • 6李敬来.CD45—淋巴细胞活化的重要调节分子[J].国外医学（免疫学分册）,2002,25(1):30-32. 被引量：13
  • 7Banerjee R,Lund RD,Radel JD.Anatomical and functional consequences of induced rejection of intracranial retinal transplants[J].Neuroscience 1993 ;56(4):939-953.
  • 8Fred F,Bettina D,Michael B,Schulze M.Embryonic stem cells share immune-priviledged features relevant for tolerance induction [J].J Mol Med 2002;80:343-350.

二级参考文献25

  • 1Taylor AW, Yee DG, Nishida T, et al. Neuropeptide regulation of immunity. The immunosuppressive activity of alpha-melanocytestimulating hormone (alpha-MSH). Ann N Y Acad Sci, 2000,917:239-247.
  • 2Streilein JW, Okamoto S, Sano Y, et al. Neural control of ocular immune privilege. Ann N Y Acad Sci, 2000,917: 297-306.
  • 3Banerjee R, Lund RD, Radel JD. Anatomical and functional consequences of induced rejection of intracranial retinal transplants. Neuroscience, 1993, 56(4):939-953.
  • 4Wenkel H, Chen PW, Ksander BR, et al. Immune privilege is extended, then withdrawn, from allogeneic tumor cell grafts placed in the subretinal space. Invest Ophthalmol Vis Sci, 1999, 40 (13):3202-3208.
  • 5Gregerson DS, Yang J. CD45-positive cells of the retina and their responsiveness to in vivo and in vitro treatment with IFN-gamma or anti-CD40. Invest Ophthalmol Vis Sci, 2003, 44(7):3083-3093.
  • 6Huang JC, Ishida M, Hersh P,et al. Preparation and transplantation of photoreceptor sheets. Curr Eye Res, 1998, 17(6):573-585.
  • 7Liversidge J, McKay D, Mullen G, et al. Retinal pigment epithelial cells modulate lymphocyte function at the blood-retina barrier by autocrine PGE2 and membrane-bound mechanisms. Cell Immunol. ,1993, 149(2): 315-330.
  • 8DiLoreto D Jr, del Cerro C, del Cerro M. Cyclosporine treatment promotes survival of human fetal neural retina transplanted to the subretinal space of the light-damaged Fischer 344 rat. Exp Neurol,1996, 140(1) :37-42.
  • 9Farrokh-Siar L, Rezai KA, Palmer EM, et al. Human fetal retinal pigment epithelium-induced cell cycle arrest, loss of mitochondrial membrane potential and apoptosis. Invest Ophthalmol Vis Sci,2000, 41(12): 3991-3998.
  • 10Lee HO, Hemdon JM, Barreiro R,et al. TRAIL: a mechanism of tumor surveillance in an immune privileged site. J Immunol, 2002,169(9): 4739-4744.

共引文献30

同被引文献15

  • 1Inoue M,Maeno T,Hatchell DL.Survival of allografted pancreatic islets in the subretinal space in rats[J].Ophthalmic Res 2003;35(1):48-53.
  • 2Ng TF,Osawa H,Hori J,Young MJ,Streilein JW.Allogeneic neonatal neuronal retina grafts display partial immune privilege in the subcapsular space of the kidney[J].J Immunol 2002;169(10):5601-5606.
  • 3Wenkel H,Streilein JW.Evidence that retinal pigment epithelium functions as an immune-privileged tissue[J].Invest Ophthalmol Vis Sci 2000;41(11):3467-3473.
  • 4Algvere PV,Gouras P,Dafgard KE.Long-term outcome of RPE allografts in non-immunosuppressed patients with AMD[J].Eur J Ophthalmol 1999;9(3):217-230.
  • 5Ma N,Streilein JW.Contribution of microglia as passenger leukocytes to the fate of intraocular neuronal retinal grafts[J].Invest Ophthalmol Vis Sci 1998;39(12):2384-2393.
  • 6Gregerson DS,Sam TN,McPherson SW.The antigen-presenting activity of fresh,adult parenchymal microglia and perivascular cells from retina1[J].J Immunol 2004;172(11):6587-6597.
  • 7Rao NA,Kimoto T,Zamir E,Giri R,Wang R,Ito S,et al.Pathogenic role of retinal microglia in experimental uveoretinitis[J].Invest Ophthalmol Vis Sci 2003;44(7):22-31.
  • 8Chant SM,Meyers-Elliott RH.Autoimmunity:a possible factor in the development of retinal degeneration in the RCS rat[J].Clin Immunol Immunopathol 1982;22(3):419-427.
  • 9Gregerson DS,Yang J.CD45-positive cells of the retina and their responsiveness to in vivo and in vitro treatment with IFN-γ or anti-CD40[J].Invest Ophthalmol Vis Sci 2003;44(7):3083-3093.
  • 10Yang PZ,Das PK,Kijlstra A.Localization and characterization of immunocompetent cells in the human retina[J].Ocul Immunol Inflamm 2000;8(3):149-157.

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2005年 第3期

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