结缔组织生长因子在眼科的研究进展

Current progress on connective tissue growth factor in ophthalmology

结缔组织生长因子(connective tissue growth factor,CTGF)是相对分子量为38kda的分泌性生长因子,属于即刻早期基因家族-CCN家族成员之一。多种组织的成纤维细胞、部分血管内皮细胞和平滑肌细胞、某些上皮细胞和肿瘤细胞以及软骨细胞等都可表达(CTGF。CTGF的主要生物学作用包括促进细胞有丝分裂和增生、细胞移行、诱导细胞粘附和胞外基质合成等。CTGF作为组织过度纤维化、瘢痕愈合和创伤修复可能的关键因子,以及在血管形成、肿瘤生长、发育分化等方面的作用,近来受到较多的关注。我们着重概述了CTGF的蛋白结构、生物学作用,回顾了近几年CTGF在眼科的研究进展。

Connective tissue growth factor (CTGF) is a 38 kDa secreted polypeptide growth factor, belong to one of the members of the CCN family of immediate early genes. Now it has been shown to be synthesized by a variety of cells including fibrob-lasts, some vascular endothellal cells and vascular smooth muscle cells, epithelial cells, tumor cells, and chondrocytes. Biological effects of CTGF include stimulation of mitosis and proliferation, cell migration, cell attachment, angiogenesis and extracellular matrix production. CTGF has recently received much attention as a possible key determinant of progressive fibrosis and excessive scarring and also of wound repair, neoangiogenesis, tumor growth and embroyonic development. We summarized the structure and biological effects of CTGF protein and reviewed the current progress on it in ophthalmology.