心脉灵液对内毒素休克大鼠肝损伤保护作用的研究

Study on the Protection Effect of Oral Liquid of Xinmailing on Hepatic Injury of Endotoxic Shock Mice

本文观察了心脉灵液对内毒素休克大鼠肝损伤的影响,结果表明,内毒素休克组6小时死亡率为90%。血清谷丙转氨酶(GPT)、谷草转氨酶(GOT)、乳酸脱氢酶(LDH)、血浆及肝脏脂质过氧化物(LPO)明显升高;肝脏超氧化物歧化酶(SOD)活性明显下降。与正常对照组相比p<0.01。心脉灵液治疗组以上指标均得到改善,与内毒素休克组相比,6小时死亡率为12.5%血清酶学、血浆及肝组织LPO水平明显下降,肝脏SOD活性明显增强,p<O.01。

The influence of oral liquid of Xinmailing on hepatic injury of endotoxic shock mice was observed. The results showed that mouse mortality of endotoxic shock group (ESG) in 6 hours was 90% , serum glutamic pyruvic transminase (GPT) , glutamic oxalacetic transminase (GOT), lactic dehydrogenase (LDH), plasma and hepatic lipid peroxide (LPO) were increased obviously and the activity of hepatic superoxide dismutase (SOD) was decreased notably. Comparying with normal group, p<0. 01. All the above-mentioned indexes were improved in the treatment group by oral liquid of Xinmailing. Mouse mortality in 6 hours was 12. 5%, seroenzyne reaction, plasma and hepatic LPO were decreased obviously, the activity of hepatic SOD was increased notably. Comparying with ESG, p<0. 01.