输送盘牵张成骨修复山羊颅骨缺损

Repair of calvarial defect by transport distraction osteogenesis in goats

目的探讨用输送盘牵张成骨技术修复山羊颅骨缺损的可行性及效果。方法选用成年雄性山羊10只,在其颅顶区制造全层骨缺损(25mm×10mm)模型。通过自行研制的两点式牵张器对其中8只动物进行输送盘骨牵张术。在牵张结束后的第4和第8周各处死4只山羊。通过X线片、组织学及扫描电镜等方法评价缺损修复和牵张间隙内新骨生成情况。另外两只不进行输送盘牵张的山羊,与固定8周实验组动物同期处死作为对照。结果实验组山羊的颅骨缺损均被成功修复,牵张间隙内有新骨再生。对照组颅骨缺损区没有自行关闭。结论输送盘牵张成骨术可以用来修复由于创伤或脑外科手术造成的颅骨缺损。

Objective To study the effect of transport distraction osteogenesis in repair of calvarial defect of goats. Methods A calvarial defect (25 mm×10 mm) and a transport disk (25 mm×(10 mm)) was created in 10 adult goats. A self-made bifocal distractor was used to repair the cranial bone defect in eight animals, of which four distracted animals were killed at the 4th and 8th weeks respectively. Gross X-Ray, histological and scanning electron microscopy were performed to evaluate the state of the bone healing and regeneration. The other two goats (sham operation control) were free from distraction but used as control after sacrifice at 8th week. Results All calvarail defects were repaired by transport distraction osteogenesis, with newly formed bone found in the distraction gap. The calvarial defects of the control goats were not healed by itself. Conclusions The technique of transport distraction osteogenesis is an alternative method for repair of calvarial defect resulting from trauma or neurosurgical operation.