摘要
目的探讨妊高征孕妇血清中可溶性Fas(sFas)的水平及意义。方法采用ELISA法测定42例妊高征孕妇(轻度7例,中度16例,重度19例)血清sFas水平,并与同期30例正常足月妊娠妇女相比较。结果(1)轻度、中度、重度妊高征组和正常妊娠组血清sFas含量分别为676.264±1.312pg/ml、874.563±1.429pg/ml、1106.587±1.287pg/ml和659.354±1.648pg/ml;(2)轻、中、重度妊高征组与正常妊娠组相比较,血清sFas含量差异有非常显著性(P.<0.001);(3)妊高征各组间比较,血清sFas含量差异有非常显著性(P<0.001)。结论随着妊高征病情加重,孕妇血清sFas水平也显著增高。提示妊高征孕妇体内存在Fas/Fas-L介导的淋巴细胞激活诱导的细胞凋亡,导致母体时胚胎的免疫排斥增强或细胞免疫不适当激活,从而导致妊高征的发生。孕妇血清sFas可以作为妊高征的预测指标之一。
Objective To determine the serum soluble Fas(sFas) levels in women with pregnancy induced hypertension(PIH). Methods The sFas levels of serum collected from 42 PIH patients and 30 normotensive pregnant women were measured by enzyme linked immunoassay (ELISA). Results Mean serum soluble Fas levels were significantly higher in mild、moderate and severe PIH group than normotensive women(676. 264±1.312pg/ml、874. 563±1. 429pg/ml and 1 106. 587±1. 287pg/ml versus 659. 354±1. 648pg/ml, P<0. 001). Conclusion Elevated serum soluble Fas is associated with PIH. It might indicate that maternal lymphocyte apoptosis by induced Fas/Fas-L and consequently lead to impaired maternal-fetal tolerance noted in PIH. Maternal serum sFas may play a marker in prediction of PIH.
出处
《贵州医药》
CAS
2005年第6期489-490,共2页
Guizhou Medical Journal
基金
本课题系贵州省科学技术基金资助项目(E98-8)
