烧伤高代谢期家兔丁胺卡那霉素药物动力学的改变

Change of amikacin pharmacokinetics in rabbits during the hypermetabolic phase after burns

３０只家兔烫伤前和烫伤后静脉注射丁胺卡那霉素（１０ｍｇ／ｋｇ）的药动学资料比较的结果表明，２０～３０％体表面积三度烫伤后１周、２周和３周家兔的丁胺卡那霉素血浓度均明显降低；药动学参数也均表现为：半衰期（Ｔ１／２）缩短、分布容积（Ｖ１和Ｖｄ）增加、清除率（ＣＬ）增加和曲线下面积（ＡＵＣ）减少。

hirty rabbits were grven wirh amikacin(10mg/kg )intravenously before and after scald burns respectively. The phar-macokinetic data showed that amikacin serum levels lowered signifecaltly in all rabbits with a third degree 20-30%TBSAburn on the day of 1、2 and 3 week postscald; the pharmacokinetic parameters also altered:the half life shortened,the destri-bution volumes(Vi and Vd )expanded,the clearance increased and the area under curve reduced.The results demonstratedthat the change of amikacin pharmacokinetics was evident drring hypermetabolic phase following thermal injury.