肝功能对环孢素血药浓度影响的监测

Influence of cyclosporine concentrations on hepatic function

６０位肾移植术后病人的１０８份ＣｓＡ血样用特异性单克隆（ＭＡＦＰＩＡ）和非特异性多克隆荧光免疫偏振分析法（ＰＡＦＰＩＡ）进行测定。结合肝脏功能与术后时间，观察药物浓度的变化。ＭＡＦＰＩＡ和ＰＡＦ－ＰＩＡ两种检测方法之间有线性关系（ｒ＝０．８９２６），二者的测得值具统计学非常显著性差异。肝功能异常的患者ＰＡＦＰＩＡ／ＭＡＦＰＩＡ比值以及回归曲线参数与肝功能正常的患者相比有明显差异，表明肝功能异常的患者ＣｓＡ的代谢产物在体内蓄积而使得检测结果偏高。术后时间对药物浓度变化有一定的作用。术后近期（１０ｄ内）与术后３～７ｗｋ服用等同剂量的ＣｓＡ，血药浓度有明显差异，说明对于肾移植术后服用ＣｓＡ的患者，应持续、定期地进行药物浓度的监测。

08 whole blood samples from 60 renal transplant recipients who had received cyclosporine( CsA)were measured withspecific monoclonal antibody( MAFPIA )and non- specific polyclonal antibody fluorescence polarization immunoassay (PAFPI-A). Linear regression analysis showed that there was a better relationship between MAFPIA and PAFPIA(r= 0.8926),PAF- PIA/MAFPIA values and linear regression curve parmeters of patients with reduced and normal hepatic function differedgreatly. The time of post-operation could be the factor of influencing CsA blood concentrations.The results suggested that the-rapeutic drug monitoring for CsA should be carried out.