肺癌病人动脉灌注和静滴环磷酰胺、阿霉素及顺铂联合用药的药物动力学比较

The comparison of pharmacokinetics of CAP regimen by bronchial arterial infusion and intravenous drip in patients with cancer

本文报道１５例肺癌病人应用ＣＡＰ方案化疗后通过测定环磷酰胺及其活性代谢物、阿霉素和顺铂的血药浓度，分别对两种不同途径给药后三种药物的药物动力学进行了比较。结果表明，三种药物支气管动脉灌注与静滴后的药动学特征均符合二室开放模型。支气管动脉灌注给药使药物清除率降低。可增加药物在体内及肺癌组织内的滞留时间，同时并不增加对肾脏的毒性。

e measured plasma level of cyclophosphamide and its active metabolite ,doxorubicin and cispiatin in 15 patients withlung cancer after regimen chemical therapy,pharmacokinetic pararneters of the three durgs by bronchial arterial infusion andintravenous drip were compared, respectively. The results showed that pharmacokinetic characteristics of the three drugs con-formed to two-compartment open model.After bronchial arterial infusion,total body clearance reduce,delay time may be in-creased in body and cancer,but nephrotoxicity wasn’t increased