摘要
本文用UV法测定健康成人口服吲哚美辛锌、吲哚美辛胶囊剂后的尿药浓度,以酸-碱法提取尿中吲哚美辛原形药,在265nm处测定吸收度,在4~32ug/ml范围内线性关系良好,平均回收率>99.0%,日内及日间RSD<0.92%,对6名健康志愿者口服给药后的药物动力学研究结果:吲哚美辛锌及吲哚美辛的药动学参数分别为,Tmax=3.32,1.87(P<0.01);K=0.1273,0.1531(P<0.05);T1/2=5.47,4.61(p<0.05);Xu(mg)=10.91,13.14(P>0.05)吲哚美锌的相对生物利用度为83.03%。
he concentration of indomethacin in urine was determined using a UV spectrophotometer at 265nm,linearity was goodover the range of 4~32ug/ml(r=0.9999),The mean recovery(both within day and between day)was more than 99.0%RSD was less than 0.92%. After a single administration of zinc-indomethacin 56mg,pharmacokinetic parameters wereTmax 3.32h,k0.1273,T1/25.47h,Xu∞10.91mg,Comparision of Tmax,K,T1/2 with indomethacin capsules showed a signifi- cunt difference (P<0.01,0.05),The relative biovailability of zinc-indomethacin capeules was 83.03%.
出处
《中国医院药学杂志》
CAS
CSCD
北大核心
1994年第5期195-197,共3页
Chinese Journal of Hospital Pharmacy
关键词
吲哚美辛锌
分光光度法
药物动力学
zinc-indomethacin, indomethacm, capsule, pharmacokinetics, bioavailability, UV-spectrophotometry