尼卡地平片溶出度测定

Study on the dissolution rate of nicardipine tablets

采用紫外分光光度法对三个厂家四个批号的尼卡地平片进行溶出度测定，求得的Ｔ５０、Ｔｄ和ｍ参数具有显著性差异（Ｐ＜０．０１），提示尼卡地平片有必要把溶出度测定作为其质量控制标准之一。

he dissolution rated of nicardipine from four batches of nicardipine tablets produced by three pharmaceutical factorieswas studied with rotation basket and UV spectrophotometry. It was found that the T50,Td and m of those samples had obviousdifference(P<0.01).It was demonstrated that the dissolution rate of nicardipine tablets should be specified in its specifica-tion.