干扰素、单磷酸阿糖腺苷、胸腺因子D治疗慢性乙型肝炎近期疗效比较

Comparision Of the recent curative effect in the treatmemt of chronic hepatitis B with inf,ara-amp and thymic factor D

作者对同一时期内的１１９例慢性乙型肝炎以干扰素、单磷酸阿糖腺苷并卡介苗、胸腺因子Ｄ并乙肝疫苗进行治疗，３个月１疗程。３组药物均有较好的降ＡＬＴ，ＳＢ和改善白球比的作用。此外均有不同程度的抑制ＨＢＶ复制的作用：３组药物的ＨＢＶ－ＤＮＡ阴转率分别为５９．１％、５３．６％、３０％、ＨＢｅＡｇ阴转率分别为５７．７％、５６．２％、３２％、而ＨＢｅＡｇ、ＨＢＶ－ＤＮＡ、抗ＨＢＣＩｇＭ三项全部阴转率分别为２４．１％、３０．６％、１６．７％。

NF,Ara-AMP and B.C.G,Thymic factor D and hepatitis B vaccine were used in 119 patients with Chronic hepatitis Bin the same period. the poriod of one course treatment was three months. All the three groups of drugs had better effect ofpulling down the ALT and SB,and of raising rate of A/G. Meanwhile,they had effect on the inhibited HBV replication to var-ious degrees.The rates of turning positive into negtive for HBV-DNA were 59.1%,53.6%,30%,for HBeAg were57.7%, 56.2%, 32%. However, all the three rates of turning positive into negtive for HBeAg, HBV-DNA and anti HBC-IgM were 24.1%,30.6%,16.7%.