普利沙星的合成与结构表征

Synthesis and Characterization of Pruliflozacin

设计了一条普利沙星的新合成路线,该合成路线工艺简单,原料易得,操作简便,收率稳定,用1H、13C、19FNMR和IR、Ms对产物结构进行了表征,结果表明产品质量可靠.新合成路线总收率为8.9%,较原合成路线的总收率高出2%,适合工业化生产.

A new synthetic route is designed for pruliflozacin. In this new route, starting materials (raw and processed materials) can be obtained easily from commercials, operations are simple and the yields are stable. The final product is characterized by 1H、13C、19F NMR and IR、 Ms. The results indicated the compound is reliably in quality. The total yields are 8.9% for pruliflozacin in this new route and over 2% than the reported route. This route is better for industrial production of pruliflozacin