电刺激大鼠苍白球对黑质Ⅰ型神经元的影响

THE EFFECTS 0F GLOBUSPALLIDUSSTIMULATI0N ON SPONTANEOUS DISCHARG6ES 0F TYPE INEURONS IN SUBSTANTIA NIGRA IN THE RAT

采用细胞外记录方法，分别观察了黑质（ＳＮ）Ⅰ型神经元对刺激苍白球（ＧＰ）内侧部及外侧部的反应。实验共记录了９６个Ⅰ型神经元。刺激ＧＰ的内侧部，有５７个（５９．３８％）神经元被顺行抑制。刺激ＧＰ的外侧部，有８６个（８９．５８％）神经元被顺行抑制；２个（２．０８％）被逆行激活，被逆行激活的神经元产生的诱发电位潜伏期恒定且短（分别为８．０和８．５ｍｓ）。被顺行抑制的神经元中，有的产生抑制、兴奋交替出现的振荡反应。本文讨论了ＧＰ与ｓＮⅠ型神经元的联系途径及ＳＮⅠ型神经元与ＧＰ的联系途径。

The responses of type I neurons of substantia nigra(SN)to stimulation of medial and later-al globus pallidus(GP)were investigated with extracellular recording in the rat. Of 96 type Ineurons recorded, 57 neurons(59.38%)were orthodromically inhibited by medial GPstimulation. 86 neurons( 89.58% ) were orthodromically inhibited and 2 neurons(2.08% )wereantidromically activated by lateral GP stimulation. The antidromically induced action potentialhad a constant short latency(8ms and 8.5ms).Oscillation with inhibitory and excitatory re-sponses occurred in some of the orthodromically inhibited neurons.The pathways connecting GPand type I neurons in SN and the connection between type I neurons and GP were discussed.