摘要
在离休豚鼠回肠标本上，ＡＣｈ诱发双相收缩反应：早期相收缩反应持续时间短，与神经节Ｎ受体有关；后期相收缩反应持续时间长，与平滑肌Ｍ受体有关。烟碱１０μｍｏｌ／Ｌ预孵育后，标本对烟碱激动神经节Ｎ受体诱发的收缩作用产生急性耐受，而ＡＣｈ激动平滑肌Ｍ受体诱发的收缩作用增强。
In isolated lieum
preparation of guinea-pig,ACh-induced contraction could be character-ized by two phases,the
initial fast contraction of short period and the subsequent slow contrac-tion of long period, which
were related to parasympathetic ganglionic nicotinic receptor andsmooth muscle muscarinic
receptor respectively.After the isolated ileum preparations had beenpreincubated with nicotine
10.0μmol / L,acute tolerance to nicotinic effect for producing initialfast contraction
developed,and supersensitization to muscarinic effect of ACh for producing con- traction was
observed.
出处
《中国应用生理学杂志》
CAS
CSCD
1994年第2期102-104,共3页
Chinese Journal of Applied Physiology
关键词
烟碱
乙酰胆碱
N受体
M受体
回肠
nicotine
acetylcholine
guinea-pig ileum,nicotinic receptor
muscarinic
receptor
