摘要
本实验采用侧脑室给药，以钾离子透入法引起大鼠甩尾反应为指标，测定动物的痛阈，发现白细胞介素－２（ＩＬ－２）具有显著提高大鼠痛阈的作用，此作用能被抗ＩＬ－２单克隆抗体所阻断。纳洛酮能反转ＩＬ－２的镇痛作用，表明其作用机理与阿片受体有关。
Using the potassium iontophoresis to
induce tail-flick as pain marker,it was found that the pain threshold was increased significantly
after injecting IL-2into the lateral ventricle of rats andthis effect was abolished by McAb to
IL-2.Naloxone could inhibit the analgesic effect of IL-2,suggesting that the analgesic effect of
IL-2 is related to the opiate receptors.
出处
《中国应用生理学杂志》
CAS
CSCD
1994年第4期322-324,共3页
Chinese Journal of Applied Physiology
关键词
白细胞介素2
痛阈
阿片受体
中枢神经系统
止痛
interleukin-2
pain threshold
opiate
receptors
lateral ventricle
central nervous system*Department of Neurobiology,The Second
Military Medical University
