摘要
目的探讨微乳作为载体促进水溶性药物盐酸哌甲酯的透皮吸收。方法以十四酸异丙酯-水-卵磷脂-乙醇作为微乳的组成部分,对微乳伪三元相图进行了研究,制备盐酸哌甲酯-卵磷脂油包水微乳,采用Franz扩散池,裸鼠离体皮肤作为透皮模型,HPLC测定药物透皮浓度,计算微乳的经皮渗透稳态流量,并与盐酸哌甲酯-卵磷脂混悬液和哌甲酯溶液作出对比。结果盐酸哌甲酯-卵磷脂油包水微乳的透皮稳态流量大于2个对照组(P<0.01)。结论微乳对盐酸哌甲酯的经皮渗透具有促进作用。
OBJECTIVE: To prepare W/O microemulsion formulation containing methylphenidate hydrochloride (MPH) and to investigate its transdermal delivery effect in vitro. METHODS: The microemulsion was prepared with the system contained of isopropyl-water-lecithin-ethanol according to the phase diagram. The steady state flux and lag time of MPH were determined in vitro using Franz diffusion cell with nude rats skin. The concentration of MPH was measured by HPLC. The transdermal characteristics of MPH microemulsion across the nude rats skin were compared with control preparations. RESULTS: The steady state flux of MPH microemulsion was significantly higher than the control preparations. CONCLUSION: Microemulsion enhanced the penetration of MPH across nude rats skin(P < 0.01).
出处
《中国药学杂志》
EI
CAS
CSCD
北大核心
2005年第11期843-845,共3页
Chinese Pharmaceutical Journal
基金
上海-SK研究与发展基金(2004011-h)
关键词
透皮
微乳
盐酸哌甲酯
Cells
Diffusion
Ethanol
Hydrochloric acid
Phase diagrams
