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冻干加热处理凝血因子类制剂的病毒灭活验证 被引量：3

Validation of virus inactivation in freeze-dried coagulation factors with heating treatment
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摘要 在病毒灭活验证过程中,比较了冻干后不同加热方法对凝血因子类制剂中伪狂犬病毒(PRV)的灭活效果,包括80℃干烤72h、100℃水浴加热30min以及100℃蒸汽加热30min方法。结果表明80℃干烤72h对制品中PRV灭活较彻底,另外两种方法对制品中PRV的灭活效果均不理想。 To compare the pseudorabies virus (PRV) inactivation efficiency in freeze-dried coagulation factors by different methods of heating treatment . The results showed that the efficiency of PRV inactivation by 80℃ baking for 72hr is better than those by 100℃ waterbath treatment for 30min and 100℃ steam heating for 30min.
作者 王剑锋 英志芳 周铁群 邱平 陈震
机构地区 中国药品生物制品检定所
出处 《微生物学免疫学进展》 2005年第2期29-31,共3页 Progress In Microbiology and Immunology
关键词 凝血因子 病毒灭活 冻干 加热处理 Coagulation factors Virus inactivation Freeze-dried Heating treatment
分类号 R954 [医药卫生—药学]
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参考文献5

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二级参考文献9

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同被引文献23

  • 1张耀,熊鸿燕,马菲,鲍作义.亚甲基蓝光化学法对全血中人免疫缺陷Ⅰ型病毒的灭活研究[J].第三军医大学学报,2004,26(21):1961-1963. 被引量：9
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  • 3程文琴,张艳宇,周锡鹏,马平,吕丽萍,许金波.钴^(60)-γ射线辐照法消毒冻干免疫球蛋白的效果观察[J].中国消毒学杂志,2007,24(4):301-305. 被引量：6
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微生物学免疫学进展
2005年 第2期

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