药物临床研究的计算机模拟

Clinical trial simulation

药物临床研究的计算机模拟是近年来刚兴起的一门交叉学科。该技术的成功运用,可大大降低新药开发费用、缩短研发时间,有广泛的应用前景。本文从药动学和药效学的角度对其发展历史、内容、方法和应用作一综述。

Clinical trial simulation is a newly evolved interdiscipline with pr o mising future. Its appropriate and successful implementation helps to reduce the cost and time of the new drug development process. In this paper, the history, application and general methodology of the technique was reviewed from the pharm acokinetics and pharmacology point of view.