磷酸钙骨水泥/聚乳酸-聚羟基乙酸生物复合材料的实验研究

Study on biocomposite of calcium phosphate cements/polyglycolic-polylactic acid

目的探讨磷酸钙骨水泥(CPC)/聚乳酸-聚羟基乙酸(PLGA)生物复合材料的理化性能,为临床应用提供理论依据。方法制备了CPC-PLGA复合材料,测定其抗压强度,通过X射线衍射(XRD)分析固化产物的物相组成、扫描电镜(SEM)观察其微观结构,并与单一的CPC材料进行对照。结果CPC-30vol%PLGA复合材料的抗压强度比单一的CPC材料提高了1倍多;与单一CPC材料相比,复合材料中CPC的固化产物羟基磷灰石晶体的聚集形态发生了改变,颗粒排列更加紧密。结论PLGA的加入可以提高CPC的抗压强度,对CPC的固化反应无不利影响,该复合材料在整形外科、骨外科及牙科领域具有较好应用前景。

[Objective]To provide theory evidence for clinical applications, some physical properties of biocomposite of calcium phosphate cements/polyglycolic-polylactic acid were investigated. The composite of calcium phosphate cements/polyglycolic-polylactic acid was prepared .The compressive strength, X-ray diffraction and Scan electron microscope analysis of CPC-PLGA were studied. The compressive strength of CPC-30vol% PLGA was twice as large as pure CPC′s, the crystal structure of HA in the composite was changed with denser structure. [Conclusion] The compressive strength of CPC can be improved by adding PLGA, in addition it has no negative influence in the solidified reaction. CPC-PLGA is a potentially useful biomaterials for orthopedics and dentistry applications.