加或不加泰素的CAF方案治疗转移性乳腺癌疗效观察

Compared CAF Combined with or without Paclitaxel in the Treatment of Advanced Breast Carcinoma.

目的:比较CAF加泰素(Paclitaxel、PLL、P)方案与单用CAF方案治疗晚期乳腺癌的疗效、生存率及毒性反应情况。方法:共治疗晚期乳腺癌52例,其中CAF方案26例,CAF加泰素方案26例。疗效评价按WHO标准评价。结果:CAF组及CAF加泰素组有效率分别为50.0%和65.4%,P<0.05,毒性反应CAF加泰素组胃肠道反应及白细胞抑制均明显高于CAF组,P<0.05。结论:两组结果相比疗效有明显差异,毒性反应有显著性差异,须重视。

Objective:To compare the efficacy and toxicity of regimen CAF with regimen CAPF.Methods:52 patients with breast cancer were enrolled , 26 patients were given CAF and the other 26 were given CAPF chemotherapy。 The treatment results were assessed according to WHO criteria.Results:The response rate of CAF and CAPF regimes are 50.0% and 65.4% (P<0.05). Compared with CAF, CAPF had higher toxic effects on digestive and hemopoietic systems(P<0.05). Conclusion:The results show that the response rate and the toxicity between the two groups are both statistically significance.