ASL脑灌注成像的应用

Brain perfusion imaging using arterial spin labeling

ASL(arterialspinlabeling)即动脉自旋标记技术 ,是一种以可自由弥散的水为内在示踪剂的MR灌注成像方法 ,它利用反转脉冲标记上游动脉血中的水质子 ,将下游成像层所获标记图像与没有标记的对照组减影而获得器官的血流量。十多年来 ,ASL已经在人类和动物身上的多种病理、生理情况下证明了其价值。本文综述其近年来的主要应用情况。

Arterial spin labeling (ASL) is a perfusion imag ing method of magnetic resonance. It applies a sequence of inversion pulses to label arterial blood water spins and uses magnetically labeled arterial water as an f reely diffusible endogenous tracer to measure cerebral blood flow. In its simple st form, the perfusion contrast in the images gathered by this technique comes f rom the subtraction of two successively acquired images: one with, and one witho ut, proximal labeling of arterial water spins after a small delay time. Over the last decade, arterial spin labeling has acquired a huge development and proven its usefulness in the study of various pathologies and physiologies, in animals or in humans. [