CD44V6和MMP-9在口腔鳞癌组织中的表达及其相关性研究

Study on the expression and correlation of MMP-9 and CD44V6 in oral squamous cell carcinoma

目的:观察MMP 9和CD44V 6在正常口腔黏膜、口腔黏膜不典型增生和口腔黏膜鳞癌的不同表达,探讨其表达规律以及异常表达与口腔黏膜癌变、转移的关系。方法:采用免疫组织化学SP法分别检测MMP 9和CD44V6在17例正常口腔黏膜、6例口腔黏膜不典型增生和5 2例口腔黏膜鳞癌的表达情况。结果:MMP 9和CD44V6在正常口腔黏膜、不典型增生的阳性表达率明显低于在鳞癌中的阳性表达率;MMP 9和CD44V6为正相关,MMP 9和CD44V6与肿瘤的转移密切相关。结论:MMP 9和CD44V6在口腔黏膜鳞癌的分化和转移过程中起重要作用,MMP 9和CD44V6的共同表达与肿瘤的不良分化和转移密切相关。

Objective:By observing and analyzing the different expressions of MMP-9 or CD44V6 at normal oral mucous?oral atypical hyperplasia and oral squamous cell carcinoma(OSCC), to investigate the relationship of their abnormal expressions?cancerate and metastasis. With immunohistochemistry to detect respectively the different expression of MMP-9 and CD44V6 at 17 cases of normal oral mucous ,6 cases of oral atypical hyperplasia and 52 OSCC.Result:①MMP-9 and CD44V6 have lower positive ration in normal oral mucous?oral atypical hyperplasia than in OSCC ;At the same time , the positive expression ratio of MMP-9?CD44V6 is increased with the differentiations degree .②MMP-9 and CD44V6 have relations with metastasis of carcinoma . Conclusion:MMP-9 and CD44V6 have important effect in metastasis and differentiations of OSCC ,the expressions of MMP-9 and CD44V6 have relationship with metastasis or differentiation of carcinoma, which provide valid method to judge the prognosis of OSCC.