我国首次研制出近红外组织血氧参数无损监测仪应用于临床

The Noninvasive Tissue Oximeter Using Near Infrared Spectroscopy (NIRS) is First Developed and Clinically Used in China

用近红外光谱(NIRS)方法实现人体组织中血氧饱和度、血红蛋白浓度的无创、连续监测是一项新兴技术。当心血管搏动微弱甚至使用体外循环时,脉搏血氧计已无读数,但组织血氧参数无损监测仪仍能提供信息。它特别适合于监测脑、肌肉、皮瓣等局部组织的血运状况。本文介绍仪器的技术指标、检测原理及临床应用。已开展的临床应用包括:新生儿脑损伤、脑发育的评定;体外循环手术过程中脑氧监测及脑的保护;组织移植后血运的监测以及骨骼肌代谢功能评定等4个方面。该仪器已由清华大学生物医学工程系研制成功,并于2005年1月通过鉴定,现已进入产品化、推广和应用阶段。用近红外光谱(NIRS)方法实现人体组织中血氧饱和度、血红蛋白浓度的无创、连续监测是一项新兴技术。在国家自然科学基金支持下,清华大学医学院生物医学工程系启动了这项技术的基础研究工作,于2002年研制成功了实验样机,并于2005年1月通过鉴定,现已进入产品化、推广和应用阶段。目前中国市场上,国外同类产品售价为3万多美元,价格很高。本样机已在5个医疗领域进行了600多例检测,目前有5台样机在5家医院长期使用,并成为临床研究所必备产品。上海复旦大学附属儿科医院将国外同类产品与本样机进行了对比测试,院方评价:“

Monitoring blood oxygen saturation and hemoglobin concentration in human tissue noninvasively and continuously using near infrared spectroscopy (NIRS) is a new-rising technique. When the cardiovascular pulsation is weak even under cardiopulmonary bypass (CPB), pulse oxygen saturation at finger tip cannot be detected, but tissue oxygenation still can be monitored by NIRS. NIRS is very suitable for the monitoring of blood transportation in the regional tissues such as human brain, muscle and flap. Its main principles, instrumentation and clinical applications are introduced. Now the oximeter using NIRS has been developed by our group, and it has been used clinically in assessing the cerebral impairments and developments of neonates, monitoring cerebral oxygenation during CPB to protect cerebral tissue against hypoxia, monitoring blood transportation in the transplanted tissues, and assessing the metabolic functions of skeletal muscles. The oximeter was approved by experts in Jan. 2005. Now it is being manufactured into product and its applications are being extended.